Immediate biofeedback for energy balance via expired breath delta(CO2)-C-13

摘要

Expired breath delta(CO2)-C-13 measured in real time serves as a useful biomarker of altered macronutrient metabolism in response to changes in energy balance. Altered breath delta(CO2)-C-13 is believed to be a result of changes in macronutrient oxidation and the kinetic isotope effect where enzymatic processes discriminate against metabolites naturally enriched with C-13. Use of breath delta(CO2)-C-13 as a rapid biofeedback of energy balance status will enhance an individual's ability to modify behavior during weight loss efforts. Herein we describe a novel approach for immediate biofeedback for energy deficit using a moderate exercise challenge. Our new mid-infrared isotope ratio-meter for delta(CO2)-C-13 is a step toward miniaturization of a personal device for instant biofeedback for people attempting to lose weight.