Ambient temperature and biomarkers of cardiovascular events

摘要

Background: Climatic, especially changes in temperature are associated with cardiovascular (CV) events but underlying mechanisms are not well understood. We examined association between air temperature and CV biomarkers such hemoglobin (Hb), fasting plasma glucose (FPG), and C-reactive protein (CRP), in type 2 diabetes patients. Methods: The subjects were (943 men and 757 women) diabetes patient resident of Pune city and suburbs. The relationship between air temperature and biomarker concentration were analysed using robust regression models. Result: Mean daily air temperature during study period varied between 15°C to 34°C. A 5°C decrease in the air temperature was associated with significant increase in arithmetic mean of Hb concentration ranging from 1.59% to 3.74%, for lag period up to 5 days before blood collection and of 3.19% and 3.80% for average last 3 and 7 days respectively. Similarly, increase in geometric mean of FPG concentration was observed for the same lag time and multidays average (4.64% to 7.76% for lags days and 6.94% and 9.67% for multi- days) whereas, CRP showed an increase of 15.26% in geometric mean (95% CI = 4.42 to 24.88) with a lag of 1-day. Conclusion: This study suggests that decrease in temperature is associated with change in several CV risk biomarkers. We need to investigate physiological and environmental mediators of this association to help improve CV risk.