Numerical Analysis of Fully-Coupled Particle-Fluid Transport and Free-Flow Magnetophoretic Sorting in Microfluidic Systems

摘要

Magnetic particles are increasingly used in microfluidic systems to selectively separate and sort biomaterial for biomedical and clinical diagnostic applications. In this presentation we introduce a computational model that can be used for the rational design of systems for such applications. The model takes into account dominant mechanisms that govern particle transport including magnetic and hydrodynamic forces, fully-coupled particle-fluid interactions and magnetic dipole-dipole interactions that induce self-assembly of the particles. We demonstrate the model via application to a continuous flow separation system and microfluidic mixing based on rotating self-assembled particle chains.