Controlled Synthesis of Monodisperse Magnetic Porous/Hollow Nanostructures for Biomedical Applications

摘要

Monodisperse magnetite Fe_3O_4 porous/hollow nanoparticles were successfully synthesized through one-pot solvothermal process without any surfactant and template. The Fe_3O_4 porous/hollow nanoparticles were synthesized controllably with tunable particle size and porosity by adjusting the initial concentrations of Fe precursor and ammonium acetate. The porous/hollow structure exhibited a great potential to encapsulate small drug molecules. Once inside the porous structures, small drug molecules would be shielded by the shell from fast reaction/deterioration in biological solutions. The porous/hollow nanoparticles could be further coupled with a specific targeting agent and be concentrated around the area of interest, where drug molecules would be released either chemically via a pH control or physically through a magnetic stimulation and activation.