Synthesis of nitroheterocycles by ionic liquids promoted 3+2-cycloaddition reactions to nitroformonitrile oxide generated by cycloreversion of dinitrofuroxan

摘要

A new approach to the synthesis of 3-nitroisoxazoles and 3-nitroisoxazolines based on the [3+2]-cycloaddition of nitroformonitrile oxide (NFNO) generated by the cycloreversion of dinitrofuroxan (DNFO) to acetylene and ethylene derivatives, accordingly, under the ionic liquids catalysis has been developed. The approach is of a general nature and applicable to cycloaddition reactions with other dipolarophiles.