Effects of Small Conductance Calcium Activated Potassium Channels in Cardiac Myocytes

摘要

Among the different potassium channels present in cardiac myocytes, the small conductance Ca2+ activated potassium channels (SK channels) are particular because they are affected by changes in intracellular calcium. The functional role of these channels in cardiac electrophysiology is still under intense debate. While they do not seem to play an important role in healthy hearts - their associated current, I_(KCa), is smaller than other potassium currents -, there is increasing evidence that they may become relevant under pathological conditions. In fact, both pro- and anti-arrhythmic effects have been assigned to these channels, depending on the clinical situation. In this work, we have incorporated the current through SK channels, I_(KCa), into an electrophysiological ionic model of human atria myocyte. This allows us to evaluate changes in the action potential under different parameters affecting the kinetics of these channels. We observe a large dependence of the action potential duration with the conductance and gate dynamics of the channel. The dependence of SK channels with changes in intracellular calcium dynamics helps decreasing the pro-arrhythmic effect of spontaneous calcium release events.