The Effect of Chronic Resveratrol Administration on Neurodegeneration and Blood Brain Barrier Stability Surrounding Intracortical Microelectrodes

摘要

Here we have found that short-term dosing of resveratrol was capable of neuroprotection up to two weeks after adminstration. However, given the time dependence of efficacy of this scheme, we established a daily administration scheme capable of maintaining a therapeutic concentration of resveratrol around implanted devices. We anticipate that our results will demonstrate the utility of resveratrol in improving long-term reliability of devices implanted into the central nervous system.