Effects of Ionizing Radiation and Dexamethasone on the Blood-Brain-Barrier (BBB) And Blood-Tumor-Barrier (BTB): Implications for Boron Neutron Capture Therapy (BNCT) Of Brain Tumors.

摘要

Currently envisioned techniques for Boron Neutron Capture Therapy (BNCT) of brain tumors rely on the increased permeability of the blood-brain-barrier (BBB) (more specifically, the blood-tumor-barrier (BTB)) which occurs around the malignant tumor. As a result of this increased permeability, higher boron concentrations (Na2B12H11SH) should be obtainable in the tumor than in the surrounding normal brain. The effects on the BBB and BTB by the ionizing component of this radiation and by the steroid dexamethasone (almost universally used in the clinical management of these patients) must be considered in the formulation of this treatment technique. 32 refs., 5 tabs. (ERA citation 14:011901)