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Sustained-released platelet-rich plasma from polyethylene glycol hydrogels exerts beneficial effects on chondrocytes

机译:来自聚乙二醇水凝胶的缓慢释放的血小板血浆对软骨细胞产生有益作用

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摘要

Taken together, these results indicate that sustained delivery of PRGF is possible through the encapsulation of PRGF in PEG hydrogels. Sustained-released PRGF from PEG hydrogels had a significant beneficial effect on chondrocyte proliferation, as well as a positive effect in the downregulation of catabolic and pro-inflammatory genes (MMP13 and NF Kappa B) in chondrocytes treated with IL-1β, as compared to a bolus PRGF dose or no PRGF treatment.
机译:总之,这些结果表明通过在PEG水凝胶中的PRGF的包封来实现PRGF的持续递送。来自PEG水凝胶的缓释PRGF对软骨细胞增殖具有显着的有益效果,以及在用IL-1β处理的软骨细胞中分解代谢和促炎基因(MMP13和NF Kappa B)的正效应,如推注PRGF剂量或没有PRGF治疗。

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