Biomaterial nanoparticles redistribute therapeutic antibodies to lymph node-resident cells to enhance cancer immunotherapy via checkpoint inhibition

摘要

We have demonstrated the ability to conjugate mAbs to lymphatic draining synthetic polymer NPs using a solvent- and denaturation-free disulfide displacement chemistry. NP conjugation enhances IgG accumulation within LNs draining the skin site of injection and lowers levels of IgG accumulation in off-target tissues. We have demonstrated the ability to reduce melanoma tumor growth using aCTLA4-NPs. These data suggest the potential of mAbs-NPs to increase the efficacy of checkpoint blockade for the treatment of advanced cancers through enhanced tumor retention and sentinel lymph node drug targeting.