Supramolecular Nanotherapeutics for Preferential Immune Modulation of the Tumor Microenvironment

摘要

This study shows that a successful strategy to overcome immune suppression and improve cancer immunotherapy could be devised by a CSF-1R inhibiting supramolecular nanotherapeutics that can alter the innate immune contexture of tumors by switching the immunosuppressive M2 macrophages to effector Ml macrophages. This study therefore can have a significant impact not only in advancing fundamental knowledge on the focal manipulation of innate immunity in the tumor, but also advance a novel immunotherapy that can potentially dramatically increase survival.