Precise control delivery of magnesium ions thru sponge-like monodispersed PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration

摘要

These results indicate that sustained and precisely controlled release of magnesium ions leads to enhanced osteoblastic bioactivity in vitro and apparent in-situ bone regeneration in vivo. Therefore, it is believed that this monodisperse PLGA/MgO-alginate core-shell microsphere system enabling precise control delivery of magnesium ions may provide a simple and cost-effective approach for local bone regeneration and healing clinically.