Multifunctional Biodegradable Porous Microspheres to Act as Stem Cell Delivery Vehicles and Local Drug Delivery Platform for Bone Tissue Regeneration

摘要

Conclusions: This unique cell carrier and drug delivery platform composed of a polymer/bioceramic composite design incorporates PLGA and HA, as well as chemically conjugated alendronate. The data from this in vitro model demonstrated that our multifunctional biomaterial supports cellular attachment and proliferation via engineered micro- and macrostructure, HA crystal precipitation and local controlled drug delivery. The results indicate we have produced a promising biomaterial strategy for both local drug delivery and stem cell-based tissue engineering and regenerative medicine.