Electrical Differentiation of Mesenchymal Stem Cells into Schwann Cell-Like Phenotypes using Inkjet Printed #Graphene Circuits

摘要

Conclusions: Our work demonstrated for the first time the transdifferention of MSCs to SC-like phenotypes solely via electrical stimuli without the need for additional chemical factors. This capability of solely electrically-induced MSC transdifferentiation has the following benefits 1) eliminates the need of arduous chemical processing steps which reduces the cost and complexity of induced cell differentiation; 2) potentially increases the spatiotemporal control of stem cell differentiation via precise electrical stimulation. These results help pave the way for in vivo peripheral nerve regeneration where the flexible graphene electrodes could conform to the injury site and provide intimate electrical simulation for nerve cell regrowth.