Prevention of Peritendinous Adhesions with Electrospun Poly(ε-caprolactone)-graft-chitosan Nanofibrous Mats

摘要

Chitosan could graft to PCL NFM while maintaining its nanofibrous structure. Taking advantage of the microporous structure of NFM, the anti-adhesion NFM could allow unhindered nutrients and wastes permeation while block cell penetration at the surgical site. The surface-grafted CS layer can reduce fibroblasts attachment, but not influence the tendon repair, and provide a long term lubricating effect to further improve the effectiveness of anti-adhesive PCL NFM after tendon surgery. PCL-g-CS NFM can effectively reduce the generation of peritendinous adhesion and is expected to enhance the healing of the tendon.