A Gold Nanoparticle-Based System to Monitor Mesenchymal Stem Cells Delivered via a PEGylated Fibrin Matrix for Ischemic Repair

摘要

This study presents a NP-based system which is capable of tracking MSCs in vivo and detecting the presence of macrophages. Macrophages which infiltrate the wound area will endocytose the delivered spherical NPs, allowing for photoacoustic detection of the cells. Future work includes in vivo studies to evaluate the benefits of delivering MSCs via a PEGylated fibrin gel, including vascular network formation and regeneration of ischemic tissue. In addition, in vivo noninvasive longitudinal US/PA imaging will be performed in order to track MSCs and monitor their role in vascular repair.