Poly(Ethylene Glycol)-Hyaluronic Acid Antioxidant Hydrogels for Prevention of Iatrogenic Cataracts

摘要

Antioxidant-loaded PEG-DA/HA hydrogels were formulated as oxygen barriers to protect the lens from oxygen-exposure during vitrectomy procedures. The material proved to meet the major design requirements for the project including: optical transparency, high elasticity, a refractive index similar to that of the lens, is polymerizable in situ, is injectable and moldable, and has low permeability to oxygen. Studies in animal models for cataract formation are currently ongoing.