Evaluation of a Gentamicin-Loaded Hydroxyapatite/Chitin Bone Cement

摘要

The GLC groups were able to sustain constant release of antibiotic over 5 days. There was a higher percent recovery of gentamicin from the 1.6% GLC (～50%) as compared to the other groups, because of the higher loading and dissolution of antibiotic. All GLC groups showed a stable and extended release of gentamicin, instead of a burst release from other antibiotic loaded bone cement systems~2. The sustained release shows that this cement is a suitable delivery vehicle for a prophylaxis agent. The compressive strength of the cement studied (7-11MPa) did not reach that the ISO 5833 standard of compressive strengths for bone cements (70MPa)~3, however, it is within the range of cancellous bone. Statistical analysis showed that gentamicin did affect the compressive strength at the 1.5% level, however, none of the samples were near the ISO standard and thus cannot be used in load bearing situations.