The role of cell shape in macrophage polarization

摘要

Elongated cell shape, independent of cytokine stimulation, induces BMDM polarization towards a pro-healing (M2) phenotype. Current work is focused on examining the molecular mechanisms underlying shape-mediated M2 polarization. In addition, we are designing biomaterials that present physical cues to promote macrophage cell elongation and M2 polarization in vivo. These studies will begin to elucidate the role of the physical microenvironment on macrophage cell polarization.