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Altered blood glucose dynamics during and after anhepatic phase of liver transplantation: A model-based approach

机译:肝移植肝阶段期间和之后血糖动态变化:一种基于模型的方法

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During liver transplantation (LT) the glucose metabolism is effected by a crucial disturbance. The blood glucose level is extremely hard to control by conventional clinical protocols during this phase. Model based approach can enhance the blood glucose control during the anhepatic phase (absence of liver) and post-anhepatic phase. The physiological constants of validated clinical metabolic model were slightly modified based on previous studies. The model fitting errors and the sufficient capture of the blood glucose (BG) dynamic evinced the applicability of the model. However the sufficient per-patient estimation of endogenous production could more enhance the performance of the model based BG prediction.
机译:在肝移植(LT)期间,葡萄糖代谢受到严重干扰的影响。在此阶段,通过常规临床方案很难控制血糖水平。基于模型的方法可以增强无肝期(无肝)和无肝期后的血糖控制。在先前的研究基础上,对经过验证的临床代谢模型的生理常数进行了轻微修改。模型拟合误差和对血糖(BG)动态的充分捕获证明了该模型的适用性。但是,每位患者对内源性生产的充分估计可以进一步提高基于模型的BG预测的性能。

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