ANALYSIS OF CELL RATIO AND DRUG CONCENTRATION INFLUENCE IN FEIGNING LUNG CANCER MODEL

摘要

Here presented is an integrated drug testing system based on a mimetic lung tissue pattern of in vitro targeted therapy testing. The integrated targeted therapy testing system consists of continuous concentration gradient platform and dielectrophoretic (DEP) cell patterning chambers. DEP forces are based on polarity difference to manipulate heterogeneous cells for mimicking the inherent lung morphology and increasing the cell-cell interaction. The multiplexed microchannels allow for simultaneous administration of multiple drug doses to functional lung cancer cells while an incorporated concentration gradient enables the in vitro dose-dependent drug responses to predict in vivo hepatotoxicity.