NanoBandage for Controlled Release of Topical Therapeutics

摘要

Burn injuries, trauma, and surgical procedures result in complex skin wounds which can lead to inflammation, infection, and scarring. Management of complex wounds remains a critical challenge for the medical community and effective, localized treatments that provide sustained drug release, are limited. Recent advancements in nanotechnology offer a unique opportunity to deliver therapeutics to wounds and improve healing. The overall goal of our work is to combine non-toxic, biodegradable nanomaterials with therapeutics in order to design a topical drug delivery system for controlled release into skin. In this study we demonstrate the potential of combining solid lipid nanoparticles (SLNs) and bacterial cellulose into a novel system for controlled topical drug delivery.