A Systems Biology and Ecology Framework for POPs Bioaccumulation in Marine Ecosystems

摘要

We propose a modelling framework for studying bioaccumulation of Persistent Organic Pollutants (POPs) and microbial bioremediation in the Adriatic food web. The integration of network estimation methods, ODE simulation and sensitivity analysis and tools from synthetic biology allows investigating multiscale effects and biological responses to POPs contamination, from the molecular level (bacteria metabolism) to the ecosystem level (food web) of a marine ecosystem.