Nanodevices and the Internet of Bio-Nano Things for Modifying Insulin Densities in Pancreatic Beta-Cells Through Electrodynamics of Ca 2+

摘要

The well-known disease the type-2 diabetes is caused mainly by the lack of production of insulin in the beta-cells inside of the islet of Langerhans. According to the dynamics of the glucose-stimulated insulin secretion, previous to the insulin production, beta-cells are depolarized due to the presence of Ca^{2+ ions. We propose the idea that the insulin might be subject to fluctuations of electric charge in time, but the average electric charge turns out to be neutral. However, upon the scenario where insulin acquires negative electric charge, the granular compounds of insulin might be electrically attracted by the Ca2+ resulting in the impairment of insulin to move out of the cells, which is the main factor to cause Type-2 diabetes. Thus a nanodevice coupled in a Internet of Bio-Nano Things might play the role for stabilize the electrodynamics of electric charge through stimulation of electric pulses that would positively affect the homeostasis of electric charge in the islet of Langerhans. We present simulations of the released insulin granules as function of the received frequency by the nano-device.}