Magnetic Solid Lipid Nanoparticles as Mediators for Controlled Hyperthermia

摘要

This paper presents the development of magnetic lipid nanoparticles that could serve as targeting delivery vehicles and heat targeted cells in a desired manner. The nanoparticles are composed of lipid matrices with low melting temperatures and fabricated by high-pressure emulsification processes at raised temperatures. Super-paramagnetic γ-Fe{sub}2O{sub}3 particles with sizes ranging from 5 to 25 nm are surface modified and dispersed evenly in the lipid nanoparticles. In the prototype demonstration, lipid nanoparticles with average sizes between 100 and 180 nm were fabricated. Meanwhile, roughly 40% to 65% of the dispersed iron oxide remained in the resulting lipid nanoparticles. When exposed to an alternating magnetic field of 60 kA/m at 25 kHz, a solution with 2 g/L encapsulated γ-Fe{sub}2O{sub}3 particles showed a temperature rise from 37 to 50°C in 20 minutes. As such, the presented solid lipid nanoparticles pioneer a new scheme of targeted and magnetically controlled hyperthermia, which is potentially applicable to a variety of medical treatments.