The basic study on application of optical coherence tomography to monitoring of viability in vivo rat brain

摘要

The relations and correlation coefficients (CCs) between the OCT signal and the modified state entropy (MSE) of electroencephalogram (EEG) have been studied. Three dimensional (3D) OCT images of rat brains through the thinned skull and EEG have been measured simultaneously anesthetizing to reduce brain activity with the quadrature fringe wide-field OCT. Measured 3D volumes are 4mm × 4mm × 2.8mm (Depth). MSE is the product of state entropy of EEG and its effective value. Depth profiles were obtained at the selected three points on the surface of thinned skull. For chosen each depth, the relative signal intensity (RSI) is defined as the ratios of signal intensity to first signal intensity. Deepening the anesthesia RSI increased and MSE decreased to show negative correlation and CCs from -0.31 to -0.56. These results indicate enhancements of the feasibility of OCT as a tool for monitoring/diagnosing the brain tissue viability.