Sistemas de Liberación Controlada de Fármacos a Partir de Materiales para la Restauración del Tejido Óseo

摘要

Nowadays, two of the most important problems are the high incidence of bone infections and the inflammatory response of the human organism when an implant is used. For this r eason, the inc lusion of dr ugs in mate rials for bone restoration is an interesting and promising a pproach to solve this problem. On this paper, drug delivery systems from bone restoration ma terials making little modifications to classic materials such as calcium phosphate cements, PMMA acrylic cements and coating metals were prepared, characterized and evaluated. All the p repared matrixes s howed n o-interaction between main c omponents of for mutation allow ing the composition to lead the beh avior of dru g profile. Th e modifications made to classic bone materials on hydrophilicity and porosity, two important characteristics, helped to improve the dr ug de livery c apacity. The e nding r esults of de livery moved between 40-95 % in different time ranges according to composition which allo ws d ifferent p ossible ap plication of these materials.