Application of Classification Algorithms on IDDM Rat Data

摘要

In our study, we intend to investigate the mechanism of tolerance induction by the modulatory and CD4 monoclonal antibody RIB 5/2 in insulin dependent diabetes mellitus rats. The aim of this investigation is to identify the key mechanisms of immune tolerance on the level of T cell, cytokine, and chemokine biomarkers in the blood, lymphatic organs, and pancreas. Additionally, it should be possible to define good biomarkers of autoimmunity and tolerance for prediction of diabetes onset. We mainly applied decision trees and later on some other classification algorithms on a rather small data set Unfortunately, the results are not significant but are good enough to satisfy our biological partners.