Biocompatible nanoparticles delivery system for Indocyanine green: synthesis and study of nanocomposites based ICG- poly (ε-caprolactone) grafted from the silica surface

摘要

Indocyanine green (ICG) has received increased attention due to its wide spread application possibilities in various biomedical fields from diagnostic to medical treatment. The fluorescent dye is approved by the FDA for a variety of medical and diagnostic applications. It is widely used as a near- infrared imaging contrast agent for in-vivo imaging applications. It absorbs strongly in the near Infrared spectral region leading to strong IR fluorescence emission, thus enabling its precise and accurate detection. Since most biomolecules do not absorb and emit in near IR-region, the fluorescence signal of ICG is relatively free of intrinsic background interference, leading to enhanced signal selectivity. However, application of ICG for in-vivo imaging is limited due to its, poor aqueous stability, its photo- degradation and concentration dependent aggregation.