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Utilization of a two construct 3D in vitro model to study the paracrine interaction of prostate cancer (CaP) cells and human osteoblasts (hOBs)

机译:利用两个构建的3D体外模型研究前列腺癌(CaP)细胞和人成骨细胞(hOB)的旁分泌相互作用

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The cellular and molecular changes of LNCaP cells seen after co-culture with TECs indicate that hOBs exert a paracrine effect on LNCaP cells and vice versa. Taken together, this model is a biological relevant model that can be used for many investigative studies pertaining to the intercellular crosstalk of CaP cells and bone.
机译:与TECs共培养后观察到的LNCaP细胞的细胞和分子变化表明,hOB对LNCaP细胞发挥旁分泌作用,反之亦然。综上所述,该模型是生物学相关的模型,可用于与CaP细胞和骨骼的细胞间串扰有关的许多调查研究。

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