Polyaspartic Acid Coated Manganese Oxide Nanoparticles for Efficent Liver MRI

摘要

With the rapid development of nanotechnology, inorganic nanoparticles (NPs) have shown great promise for diagnostic and therapeutic applications. Monodispersed NPs with uniform and controlled shape and size are typically synthesized by high temperature thermal decomposition methods.For manganese oxide nanoparticles (MONPs) which have been developed as T_1 contrast agents for magnetic resonance imaging (MRI), several polymer materials have been chosen for surface coating, the most common one being PEGylated phospholipid (PL-PEG). However, the n relaxivity of PL-PEG-MONPs is rather low (for example, the r_1 value of 20 nm MONPs reported by the Hyeon group was as low as 0.13 mM~(-1) s~(-1) on a 3.0 T MRI). Previously, our group reported that HSA coated MONPs showed a high n of 1.97 mM~(-1)s~(-1). Polyaspartic acids (PASP) is a biocompatible and biodegradable polymer which has been used to coat quantum dots (QDs) and iron oxide nanopartides.