Substrate topography modulation in endocytosis: a tool for drug and gene delivery

摘要

Topographical cues are presents in the extracellular matrix environment that the cells reside in. The importance of topographical cues in modulating cell behaviors has become increasingly evident in recent studies. Endocytosis is a fundamental biological process and it is also the key mechanism for drug and non-viral gene delivery. However, the influence of topography on endocytosis has only been sparsely studied. We hypothesize that topography can enhance cellular endocytosis, and in turn the non-viral transfection efficiency.