Collagen/chitosan scaffolds loaded with TMC/siRNA-TGF-β1 complexes for skin scarless repair

摘要

TMC/siRNA-TGF-β1 complexes could induce significant gene knockdown at N/P ratio 20 both in 2-D culture and 3-D collagen/chitosan scaffold. The siRNA-loaded BDE induces down-regulation of TGF-β1 and scar-inhibition during skin repair in vivo. The combination of RNA interference and regenerative medicine materials to down-regulate TGF-pi may open a new way to realize the full regeneration of skin. Acknowledgment: Financial support by the Natural Science Foundation of China (50873088, 20934003), and the Major State Basic Research Program of China (2011CB606203).