Grafting of polyNaSS increased the hydrophilic character of the surface and modified the affinities and conformation of adsorbed proteins. The adsorption of fibrinogen and fibronectin increased the staphylococcal adhesion whereas albumin inhibited it. The protein environment on the surface of the Ti_6Al_4V strongly affected the bacterial response but it is only a part of a complex system of interactions between bacteria and the biomaterial surface. The surface midifications induced by polyNaSS may be regulating the exposure of important protein motifs involved in bacterial adhesion.
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