Biocompatibility of Microencapsulated Chitosan, Nano-HA/Collagen and Poly(L-Lactide)-based Microsphere-Scaffold Delivery System

摘要

The present study demonstrated that the CMs/nHAC/PLLA microsphere-scaffold composite can improve the morphology of MC3T3-E1 cells in vitro and accelerate the regeneration of femoral condyle defect with a diameter of 6 mm in vivo as compared with the control nHAC/PLLA scaffold. The excellent biocompatibility of the CMs/nHAC/PLLA composite was attributed to both the chitosan component and the bioactive synthetic peptide encapsulated inside. The successful microsphere based scaffold release system offers an innovation for the delivery of growth factors and a novel scaffold configuration for a variety of tissue regeneration application.