Endothelialization of Vascular Prosthesis in a Pig Model of Peripheral Bypass Graft

摘要

Minipig represents surgically more suitable model than domestic pig. The most durable surgical setting seems to be bilateral aortic-internal iliac bypass graft with ligature of the external iliac arteries. Endothelial cells can be harvested from the jugular vein, cultured and seeded onto PET vascular prosthesis by providing a fibrin / fibronectin substratum. Seeding of own endothelial cells onto the vascular prosthesis may inhance the bypass graft patency in a minipig model.