Overnight Closed-Loop Insulin Delivery in Patients with Type 1 Diabetes

摘要

The artificial pancreas or automated closed-loop insulin delivery system is an emerging technology to treat type 1 diabetes aiming to safely achieve and maintain near normal glucose levels. The main components are a continuous glucose monitor, a subcutaneous insulin infusion pump and a control algorithm, which computes, in real-time, the amount of insulin to be delivered by the pump. The research focus at the University of Cambridge is to develop a closed-loop system prototype for overnight use employing off-the-shelf devices and using model predictive control algorithm. We have tested the closed-loop system overnight in both younger and older patient with T1D, demonstrating improvement in glucose control and reduction in nocturnal hypoglycemia.