Melt Extrusion for the Enablement of Pharmaceutical Products - Case Study Using Griseofulvin

摘要

Melt extrusion has gained significant interest in the pharmaceutical industry due to the continuous nature and ability to provide unique dosage form characteristics. Enhancement of oral bioavailability to enable drug products has been exploited extensively using melt extrusion. In this study melt extrusion was used for the preparation of griseofulvin solid dispersions. Using this technology amorphous formulations of drug and non-ionic polymers were prepared. Compositions were evaluated for physical characteristics, chemical performance and dissolution rate. Results showed that all formulations could be prepared below the melting temperature of the drug substance and the resulting formulations provided significant levels of supersaturation during dissolution testing.