Angiogenic Switch - Mixed Spatial Evolutionary Game Approach

摘要

The main goal of this paper is to study properties of a game theoretic model of an angiogenic switch using Mixed Spatial Evolutionary Games (MSEG). These games are played on multiple lattices corresponding to the possible phenotypes and give the possibility to simulate and investigate heterogeneity on the player-level in addition to the population-level. Furthermore, diverse polymorphic equilibrium points dependent on individuals reproduction, model parameters and their simulation are discussed. The analysis demonstrates the sensitivity properties of MSEGs and the possibility for further development of spatial games.