Synthesis and Characterization of temperature-sensitive oligo(ethylene glycol) grafted poly(L-glutamate) copoly mers

摘要

A series of novel temperature-sensitive oligo(ethylene glycol) grafted poly(L-glutamate) were synthesized and characterized. The copolymers exhibited sharp phase transitions with the increase in temperature. The LCST of the copolymer could be adjusted from 25 °C to 73 °C by varying the PPLG backbone length and the OEG side chain length. Since they exhibited LCSTs around the physiological temperature, the novel biodegradable and biocompatible polypeptide-based copolymers may have potential in biomedical applications.