Drug Eluting Stents: Controlled Drug Release Using Magnesium Alloy Coatings

摘要

We have been able to sputter coat pure magnesium and magnesium alloy AZ31 on the surface of paclitaxel-covered cobalt chromium. The sputtered pure magnesium coat slowed down the release rate of paclitaxel from the surface. Sputtered magnesium alloy AZ31 further reduces the release rate. There is a significant difference (p<0.05) in the Paclitaxel release from the different coat thicknesses. Thicker coats of both pure magnesium and magnesium alloy slow down PAT release in the first 2 h.