Mixed Micelles Composed of PEG-lipids and Cytotoxic Peptide Amphiphiles for Cancer Therapy

摘要

This work demonstrates that therapeutic peptides can be incorporated into self-assembled micelles with PEG-lipids. The mode of action of the cytotoxic peptide amphiphile was altered depending on how the peptide was displayed to the cells. This results from this work show that PEG-lipids will be able to protect therapeutic peptides during circulation. Previous work has demonstrated that micelles constructed from peptide-PEG-lipids can deliver imaging agents to tumors in vivo. Future work will include targeting peptides at the end of the PEG chains to specifically deliver these therapeutic peptides to cancer in vivo. This platform has the potential to deliver not only D-(KLAKLAK)2 as a therapeutic to many types of cancers, but also provide a blueprint for an effective way to deliver a wide variety of peptide therapeutics to their disease targets.