Mechanical Properties and Loading Techniques of Mucoadhesive Films for Treatment of Oral Dysplasia

摘要

Although cyclodextrin can complex with imiquimod and increase its solubility, it was not sufficient to achieve clinically required doses in films, but this could be achieved by using acetate buffer. The 2:3 PVP:CMC films are a good choice with a compromise between obtaining sustained imiquimod release and robust mechanical and shear adhesive properties.