Microparticle-mediated Nox2-siRNA therapy for preventing cardiac dysfunction following myocardial infarction

摘要

Following MI, there is a robust inflammatory response involving phagocytic cells (neutrolphils, monocytes, macrophages) that are traditionally hard to deliver siRNA to. While many studies show Nox2 is a possible therapeutic target, to date no successful siRNA therapy has been reported. Our preliminary studies demonstrate that Nox2 siRNA can be encapsulated within polyketal particles, which serve as excellent delivery vehicles for macrophages. Successful completion of these studies could lead to a novel treatment for post-infarction injury and to large animal testing of polyketal particles for treating myocardial infarction.