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Targeting the SIRPal Signaling Pathway to Reduce the Inflammatory Response to Polymeric Surfaces

机译:靶向SIRPal信号通路以减少对聚合物表面的炎症反应

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Functionalizing polymeric surfaces with antibodies specific for the extracellular domain of SIRPal can inhibit inflammatory cell interactions with synthetic surfaces. The anti-SIRPal antibody appears to act as an agonist for the SIRPal receptor and initiated a signal transduction cascade as evident from the phosphorylation of SIRPal and myosin Ha.
机译:用对SIRPal的胞外域具有特异性的抗体官能化聚合物表面可以抑制炎性细胞与合成表面的相互作用。从SIRPal和肌球蛋白Ha的磷酸化可以明显看出,抗SIRPal抗体似乎充当SIRPal受体的激动剂并启动了信号转导级联反应。

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