Role of Integrin Subunits in Osteoblast Maturation on Microstructured Surfaces with Different Chemistries

摘要

This study examined the effect of surface chemistry on osteoblast maturation using substrates with the same roughness. Lack of osteoblast differentiation in integrin pi-silenced MG63 cells on surfaces with similar roughness but different chemistries suggests a major role of the integrin pi subunit in roughness recognition. Interestingly, integrin al and a2 silencing affected osteoblast maturation on titanium surfaces, but failed to affect osteoblast behavior on carbon-coated surfaces. Integrin av silencing was the only subunit that affected osteoblast maturation on carbon-coated substrates. These results suggest that integrin alpha subunits play a major role in the surface chemistry recognition.