Platelet-Rich Plasma: An autologous agent for MSC migration, proliferation, delivery, and cryopreservation for regenerative medicine

摘要

Providing insight on the regenerative effects of PRP, we found that the quantified growth factors stimulated the migration and proliferation of MSC isolated from bone marrow and cortical bone tissue. We identified umbilical cord blood as a potent new source of PRP. Further, PRP can be used as injectable material for cell & microparticle delivery in tissue engineering applications & as an autologous cryopreservation medium for MSC and scaffolds, allowing for long-term storage & direct administration to patients.