Characterizing pH-Responsive Nanoparticlcs for Treatment of Mesothelioma Malignancies

摘要

pH-responsive expansile nanoparticles are a novel drug carrier device with a reliable trigger (pH) and mechanism of action (swelling). Both microscopic and macroscopic investigations confirm this mechanism of action. Additionally, introduction of nanoparticles into a cellular environment does not adversely affect the particle functionality. The decrease in cell viability subsequent to administration of paclitaxel-loaded nanoparticles to tumor cells also suggests that these particles effectively release therapeutic levels of drug.