Evaluation of Emerging technologies (Stents and Valves) in Animal Models: Biological Responses, Time Points and Beyond

摘要

The proof of performance concept, safety and efficacy of emerging technologies is best evaluated in animal models. Though increasing sophistication in device development, animal medicine, and model design has provided sophisticated tools preclinical models for endovascular stents and percutaneous valves remain a challenge. Accepted models are limited as evolving technology is extended into arteries of smaller diameter, increased tortuosity, bifurcations and use with multiple stents. Percutaneous valves present structural and geometric demands as well. Quantification of effect creates further needs with far greater attention paid than ever before to precise definition of device performance.