Thermo-responsive poly-A'-isopropylacrylamide as an adjuvant in experimental rheumatoid arthritis

摘要

The synthesized thermo-responsive PNiPAAm showed the temperature dependent phase transition. The CII mixed with PNiPAAm precipitated inside the body (gelation) and released antigen slowly for a longer period. The CII did not change its native conformation after mixing with polymer and induced significant anti-CII antibody response and arthritis. Therefore, biodegradable thermo-responsive polymers can be used as an adjuvant to study not only autoimmuity but also arthritis development.